How do smoking and HLA-DRB1 interact in RA?

Cigarette smoking has been identified as a major environmental risk factor for developing rheumatoid arthritis (RA), especially in individuals who carry the HLA-DRB1 shared epitope genetic variant. The interaction between smoking and HLA-DRB1 significantly increases the risk of developing RA and may also contribute to more severe disease progression. Smoking is thought to trigger an immune response in individuals with the HLA-DRB1 gene variant, leading to the development of autoimmune arthritis. Consequently, smoking cessation is recommended as a primary preventative measure for individuals at risk of RA, particularly those with the HLA-DRB1 gene variant.
This mind map was published on 9 April 2024 and has been viewed 50 times.

You May Also Like

What skills do I need to be promoted quickly?

What strategies can local administration adopt for efficient resource management?

Can anyone become an alpha male or is it innate?

What are the most popular types of collectibles?

What are the requirements for skilled plumber migration in New Zealand?

How does coolmindmaps.com generate mind maps?

What are the mechanisms of smoking and HLA-DRB1 interaction in RA?

Quais são os principais ossos do crânio?

What are the different types of organic growth?

What are the different types of internal growth strategies?

What are the advantages of using internal growth methods?

How can companies implement organic growth?