How do TRP channels affect body temperature?

Transient receptor potential (TRP) channels are involved in thermoregulation and play a significant role in modulating body temperature. These channels are present in various tissues, including sensory neurons in the skin and hypothalamus, which are responsible for detecting changes in body temperature. Activation of TRP channels by temperature fluctuations initiates a signaling cascade that results in the release of neurotransmitters and hormones, leading to vasoconstriction or vasodilation and sweating or shivering, ultimately affecting body temperature. Dysregulation or mutations of TRP channels have been linked to abnormal temperature responses, including increased sensitivity to cold or heat.
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